Article
MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?
Oncotarget - 15 Sept 2015
Brunetti Oronzo, Russo Antonio, Scarpa Aldo, Santini Daniele, Reni Michele, Bittoni Alessandro, Azzariti Amalia, Aprile Giuseppe, Delcuratolo Sabina, Signorile Michele, Gnoni Antonio, Palermo Loredana, Lorusso Vito, Cascinu Stefano, Silvestris Nicola
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a poor prognosis, short overall survival and few chemotherapeutic choices. MicroRNAs (miRNAs) are non-coding, single-stranded RNAs of around 22 nucleotides involved in the pathogenic mechanisms of carcinogenesis and metastasis. They have been studied in many tumors in order to identify potential diagnostic, prognostic or therapeutic targets. In the current...
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