Article
A study of the neuropathy associated with transthyretin amyloidosis (ATTR) in the UK.
Journal of neurology, neurosurgery, and psychiatry - 1 Jun 2016
Carr A S, Pelayo-Negro A L, Evans M Rb, Laurà M, Blake J, Stancanelli C, Iodice V, Wechalekar A D, Whelan C J, Gillmore J D, Hawkins P N, Reilly M M
Abstract excerpt
BACKGROUND: Hereditary transthyretin amyloidosis (ATTR) is usually characterised by a progressive peripheral and autonomic neuropathy often with associated cardiac failure and is due to dominantly inherited transthyretin mutations causing accelerated amyloid deposition. The UK population is unique in that the majority of patients have the T60A missense mutation in ATTR where tyrosine is replaced by adenine at...
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