Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potentially Beneficial Effect of Hydroxychloroquine in a Patient with a Novel Mutation in Protein Kinase Cδ Deficiency.

Journal of clinical immunology - 1 Aug 2015

Kiykim Ayca, Ogulur Ismail, Baris Safa, Salzer Elisabeth, Karakoc-Aydiner Elif, Ozen Ahmet Oguzhan, Garncarz Wojciech, Hirschmugl Tatjana, Krolo Ana, Yucelten Ayse Deniz, Boztug Kaan, Barlan Isil B

Abstract excerpt

Protein kinase C delta (PRKCD) has essential functions in controlling B-cell proliferation and apoptosis, development of B-cell tolerance and NK-cell cytolitic activity. Human PRKCD deficiency was recently identified to be causative for an autoimmune lymphoproliferative syndrome like disorder wit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antirheumatic Agents
Share to Autoimmune Lymphoproliferative Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Cytomegalovirus Infections

Share to Hydroxychloroquine

Share to Killer Cells, Natural

Share to Lupus Erythematosus, Systemic

Share to Protein Kinase C-delta

Source

Identifiers

PMID: 26233237
DOI: 10.1007/s10875-015-0178-9

Genes

PRKCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26233237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Potentially Beneficial Effect of Hydroxychloroquine in a Patient with a Novel Mutation in Protein Kinase Cδ Deficiency.PMID 26233237Read ↗

Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature.Semantic proximity Read ↗

Human DNA-dependent protein kinase catalytic subunit deficiency: A comprehensive review and update.Semantic proximity Read ↗

Sirolimus is effective in autoimmune lymphoproliferative syndrome-type III: A pedigree case report with homozygous variation PRKCD.Semantic proximity Read ↗

Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.Semantic proximity Read ↗

Protein Kinase C δ: a Gatekeeper of Immune Homeostasis.Semantic proximity Read ↗

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.Semantic proximity Read ↗

Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δSemantic proximity Read ↗

Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans.Semantic proximity Read ↗

B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.