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Article

DEPDC5 mutations are not a frequent cause of familial temporal lobe epilepsy.

Epilepsia - 1 Oct 2015

Striano Pasquale, Serioli Elena, Santulli Lia, Manna Ida, Labate Angelo, Dazzo Emanuela, Pasini Elena, Gambardella Antonio, Michelucci Roberto, Striano Salvatore, Nobile Carlo

Abstract excerpt

Mutations in the DEPDC5 (DEP domain-containing protein 5) gene are a major cause of familial focal epilepsy with variable foci (FFEVF) and are predicted to account for 12-37% of families with inherited focal epilepsies. To assess the clinical impact of DEPDC5 mutations in familial temporal lobe epilepsy, we screened a collection of Italian families with either autosomal dominant lateral temporal epilepsy (ADLTE)...

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Source

Identifiers

PMID: 26216793
DOI: 10.1111/epi.13094

Genes

DEPDC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DEPDC5 mutations are not a frequent cause of familial temporal lobe epilepsy.PMID 26216793Read ↗

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