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Article

Rescuing chemotaxis of the anticancer agent Salmonella enterica serovar Typhimurium VNP20009.

Journal of biotechnology - 10 Oct 2015

Broadway Katherine M, Denson Elizabeth A P, Jensen Roderick V, Scharf Birgit E

Abstract excerpt

The role of chemotaxis and motility in Salmonella enterica serovar Typhimurium tumor colonization remains unclear. We determined through swim plate assays that the well-established anticancer agent S. Typhimurium VNP20009 is deficient in chemotaxis, and that this phenotype is suppressible. Through genome sequencing, we revealed that VNP20009 and four selected suppressor mutants had a single nucleotide...

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PMID: 26200833
DOI: 10.1016/j.jbiotec.2015.07.010

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