Article
Determining the genome-wide kinship coefficient seems unhelpful in distinguishing consanguineous couples with a high versus low risk for adverse reproductive outcome.
BMC medical genetics - 20 Jul 2015
Kelmemi W, Teeuw M E, Bochdanovits Z, Ouburg S, Jonker M A, Alkuraya F, Hashem M, Kayserili H, van Haeringen A, Sheridan E, Masri A, Cobben J M, Rizzu P, Kostense P J, Dommering C J, Henneman L, Bouhamed-Chaabouni H, Heutink P, Ten Kate L P, Cornel M C
Abstract excerpt
BACKGROUND: Offspring of consanguineous couples are at increased risk of congenital disorders. The risk increases as parents are more closely related. Individuals that have the same degree of relatedness according to their pedigree, show variable genomic kinship coefficients. To investigate whether we can differentiate between couples with high- and low risk for offspring with congenital disorders, we have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.