Article
Androgen Insensitivity Syndrome: Management Considerations from Infancy to Adulthood.
Pediatric endocrinology reviews : PER - 1 Jun 2015
Chen Min-Jye, Vu Bach-Mai K, Axelrad Marni, Dietrich Jennifer E, Gargollo Patricio, Gunn Sheila, Macias Charles G, McCullough Laurence B, Roth David R, Sutton V Reid, Karaviti Lefkothea P
Abstract excerpt
Androgen insensitivity syndrome (AIS) is an undervirilization syndrome in individuals with 46, XY karyotype. The undervirilization can be complete feminization or incomplete virilization with grades of ambiguity. AIS is caused by mutations in the androgen receptor, resulting in resistance to the physiologic activities of androgens. Differing degrees of resistance lead to three phenotypes: a complete form with...
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