[The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera patients with JAK2 V617F mutation].

doi:10.3760/cma.j.issn.0253-2727.2015.06.016

Back to search

Article

[The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera patients with JAK2 V617F mutation].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jun 2015

Dong Lu, Shen Xuliang, Wei Wu, Shi Wenzhi, Zhang Guoxiang, Cao Wenjun, Li Dan

Abstract excerpt

OBJECTIVE: To detect the activity of autophagy and explore the impact on survival and proliferation of HEL cells and hematopoietic cells of polycythemia vera （PV） patients with JAK2 V617F mutation. METHODS: Flow cytometry, AO staining and Western blot methods were used to detect the autophagy activity and the expression of LC3-Ⅱ protein of JAK2 V617F+ HEL cells and hematopoietic cells of 12 newly diagnosed PV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to JAK2 gene

Share to Janus Kinase 2

Share to Mutation

Share to Polycythemia Vera

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

[The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera patients with JAK2 V617F mutation].PMID 26134021Read

Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignanciesSemantic proximity Read

An Overview of the Perspective of Cellular AutophagySemantic proximity Read

Autophagy as a target for hematological malignancy therapySemantic proximity Read

Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug developmentSemantic proximity Read

Mechanistic roles of autophagy in hematopoietic differentiationSemantic proximity Read

The Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in TumorsSemantic proximity Read

Autophagy, a key mechanism of oncogenesis and resistance in leukemiaSemantic proximity Read

Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disordersSemantic proximity Read