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Article

Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.

PloS one - 1 Jan 2015

Blancafort Adriana, Giró-Perafita Ariadna, Oliveras Glòria, Palomeras Sònia, Turrado Carlos, Campuzano Òscar, Carrión-Salip Dolors, Massaguer Anna, Brugada Ramon, Palafox Marta, Gómez-Miragaya Jorge, González-Suárez Eva, Puig Teresa

Abstract excerpt

Blocking the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of HER2-positive breast carcinoma cells. The hypothesis is that blocking FASN, in combination with anti-HER2 signaling agents, would be an effective antitumor strategy in preclinical HER2+ breast cancer models of trastuzumab and lapatinib resistance. We developed and molecularly characterized in vitro HER2+ models of resistance to trastuzumab...

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Source

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Identifiers

PMID: 26107737
DOI: 10.1371/journal.pone.0131241
PMCID: PMC4479882

Genes

FASN
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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