FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study.

doi:10.1620/tjem.236.219

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Article

FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study.

The Tohoku journal of experimental medicine - 1 Jul 2015

Cong Lei, Wang Wei-bo, Liu Qi, Du Jia-jun

Abstract excerpt

Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). The FokI polymorphism (rs10735810) represents a T-to-C transition (ATG to ACG) in exon 2 of the VDR gene, and this ATG represents the translation-initiation codon, encoded by the f allele. The FokI polymorphism results in the generation of a protein shortened by three amino acids, translated...

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PMID: 26105695
DOI: 10.1620/tjem.236.219

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