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Article

Improved growth velocity of a patient with Noonan-like syndrome with loose anagen hair (NS/LAH) without growth hormone deficiency by low-dose growth hormone therapy.

American journal of medical genetics. Part A - 1 Oct 2015

Takasawa Kei, Takishima Shigeru, Morioka Chikako, Nishioka Masato, Ohashi Hirofumi, Aoki Yoko, Shimohira Masayuki, Kashimada Kenichi, Morio Tomohiro

Abstract excerpt

Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) is caused by a heterozygous c.4A>G mutation in SHOC2. Most cases exhibit both growth hormone deficiency (GHD) and growth hormone insensitivity (GHI) and thus require a high dose of growth hormone (GH) therapy (e.g., 35-40 µg/kg/day). We report on a genetically diagnosed NS/LAH patient manifesting severe short stature (-3.85 SDs) with low serum...

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PMID: 26096762
DOI: 10.1002/ajmg.a.37191

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IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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