Article
Ruxolitinib in combination with lenalidomide as therapy for patients with myelofibrosis.
Haematologica - 1 Aug 2015
Daver Naval, Cortes Jorge, Newberry Kate, Jabbour Elias, Zhou Lingsha, Wang Xuemei, Pierce Sherry, Kadia Tapan, Sasaki Koji, Borthakur Gautam, Ravandi Farhad, Pemmaraju Naveen, Kantarjian Hagop, Verstovsek Srdan
Abstract excerpt
Ruxolitinib and lenalidomide may target distinct clinical and pathological manifestations of myelofibrosis and prevent therapy-related worsening of blood cell counts. To determine the efficacy and safety of the combination in patients with myelofibrosis, patients were given 15 mg ruxolitinib orally twice daily in continuous 28-day cycles, plus 5 mg lenalidomide orally once daily on days 1-21. Thirty-one patients...
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