Article
Using noise to control heterogeneity of isogenic populations in homogenous environments.
Physical biology - 18 Jun 2015
Szymańska Paulina, Gritti Nicola, Keegstra Johannes M, Soltani Mohammad, Munsky Brian
Abstract excerpt
We explore the extent to which the phenotypes of individual, genetically identical cells can be controlled independently from each other using only a single homogeneous environmental input. We show that such control is theoretically impossible if restricted to a deterministic setting, but it can be achieved readily if one exploits heterogeneities introduced at the single-cell level due to stochastic fluctuations...
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