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Antiepileptic drugs in patients with malignant brain tumor: beyond seizures and pharmacokinetics

21 May 2015

Abstract excerpt

In neurological malignancies, antiepileptic drugs (AEDs) are frequently used to control the seizure activity that accompanies the disorder. There is a growing body of evidence on the importance of AED selection for reasons other than pharmacokinetics (PK) properties. Epigenetic modifications may occur in glioblastomas, such as changes in gene methylation and histone acetylation states. Secondary mechanisms of AED...

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PMID: 25996875
DOI: 10.1111/ane.12437

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