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Article

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

PloS one - 1 Jan 2015

Yasunami Michio, Nakamura Hitomi, Agematsu Kazunaga, Nakamura Akinori, Yazaki Masahide, Kishida Dai, Yachie Akihiro, Toma Tomoko, Masumoto Junya, Ida Hiroaki, Koga Tomohiro, Kawakami Atsushi, Eguchi Katsumi, Furukawa Hiroshi, Nakamura Tadashi, Nakamura Minoru, Migita Kiyoshi

Abstract excerpt

OBJECTIVES: The genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk of FMF was examined as strong candidates of modifier genes. METHODS: Genotypes of HLA-B and -DRB1 loci...

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Identifiers

PMID: 25974247
DOI: 10.1371/journal.pone.0125938
PMCID: PMC4431852

Genes

MEFV

Variants

Provenance

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