Article
Rate, spectrum, and evolutionary dynamics of spontaneous epimutations.
Proceedings of the National Academy of Sciences of the United States of America - 26 May 2015
van der Graaf Adriaan, Wardenaar René, Neumann Drexel A, Taudt Aaron, Shaw Ruth G, Jansen Ritsert C, Schmitz Robert J, Colomé-Tatché Maria, Johannes Frank
Abstract excerpt
Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We...
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