Article
Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2015
Khan Sofia, Fagerholm Rainer, Rafiq Sajjad, Tapper William, Aittomäki Kristiina, Liu Jianjun, Blomqvist Carl, Eccles Diana, Nevanlinna Heli
Abstract excerpt
PURPOSE: Although most patients with estrogen receptor (ER)-positive breast cancer benefit from endocrine therapies, a significant proportion do not. Our aim was to identify inherited genetic variations that might predict survival among patients receiving adjuvant endocrine therapies. EXPERIMENTAL DESIGN: We performed a meta-analysis of two genome-wide studies; Helsinki Breast Cancer Study, 805 patients, with 240...
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