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Article

Phenotype-dependent alteration of pathways and networks reveals a pure synergistic mechanism for compounds treating mouse cerebral ischemia.

Acta pharmacologica Sinica - 1 Jun 2015

Wang Peng-qian, Li Bing, Liu Jun, Zhang Ying-ying, Yu Ya-nan, Zhang Xiao-xu, Yuan Ye, Guo Zhi-li, Wu Hong-li, Li Hai-xia, Dang Hai-xia, Guo Shan-shan, Wang Zhong

Abstract excerpt

AIM: Our previous studies have showed that ursodeoxycholic acid (UA) and jasminoidin (JA) effectively reduce cerebral infarct volume in mice. In this study we explored the pure synergistic mechanism of these compounds in treatment of mouse cerebral ischemia, which was defined as synergistic actions specific for phenotype variations after excluding interference from ineffective compounds. METHODS: Mice with focal...

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Identifiers

PMID: 25960134
DOI: 10.1038/aps.2014.168
PMCID: PMC4594188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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