Article
MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression.
Journal of translational medicine - 7 May 2015
Mancuso Roberta, Hernis Ambra, Agostini Simone, Rovaris Marco, Caputo Domenico, Clerici Mario
Abstract excerpt
BACKGROUND: Demyelination and failure of remyelination are core mechanisms in the pathogenesis of multiple sclerosis (MS); the factor(s) modulating these processes are still mostly unknown. MicroRNA 572 (miR-572) is deregulated in MS and is suggested to targets neural cell adhesion molecule (NCAM), a glycoprotein involved in CNS reparative mechanisms. The aim of this study is to analyze miR-572 in patients with...
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