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Article

Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase.

Molecules and cells - 1 May 2015

Jang Do Soo, Choi Gildon, Cha Hyung Jin, Shin Sejeong, Hong Bee Hak, Lee Hyeong Ju, Lee Hee Cheon, Choi Kwan Yong

Abstract excerpt

Low-barrier hydrogen bonds (LBHBs) have been proposed to have important influences on the enormous reaction rate increases achieved by many enzymes. Δ(5)-3-ketosteroid isomerase (KSI) catalyzes the allylic isomerization of Δ(5)-3-ketosteroid to its conjugated Δ(4)-isomers at a rate that approaches the diffusion limit. Tyr14, a catalytic residue of KSI, has been hypothesized to form an LBHB with the oxyanion of a...

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Identifiers

PMID: 25947291
DOI: 10.14348/molcells.2015.2266
PMCID: PMC4443282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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