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Article

Glioblastoma multiforme in a child with tuberous sclerosis complex.

American journal of medical genetics. Part A - 1 Oct 2015

Vignoli Aglaia, Lesma Elena, Alfano Rosa Maria, Peron Angela, Scornavacca Giulia Federica, Massimino Maura, Schiavello Elisabetta, Ancona Silvia, Cerati Michele, Bulfamante Gaetano, Gorio Alfredo, Canevini Maria Paola

Abstract excerpt

Tuberous Sclerosis Complex (TSC) is characterized by the presence of benign tumors in the brain, kidneys, heart, eyes, lungs, and skin. The typical brain lesions are cortical tubers, subependimal nodules and subependymal giant-cell astrocytomas. The occurrence of malignant astrocytomas such as glioblastoma is rare. We report on a child with a clinical diagnosis of TSC and a rapidly evolving glioblastoma...

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Identifiers

PMID: 25946256
DOI: 10.1002/ajmg.a.37158

Genes

TSC2

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