Article
Treatment of hepatitis C in patients with cirrhosis: remaining challenges for direct-acting antiviral therapy.
Drugs - 1 May 2015
Majumdar Avik, Kitson Matthew T, Roberts Stuart K
Abstract excerpt
Chronic hepatitis C virus (HCV) infection is a major global health concern, resulting in significant morbidity and mortality. Treatment using interferon-based therapy in patients with HCV-related cirrhosis has been problematic due to toxicity and poor tolerability. Furthermore, interferon therapy is contraindicated in those with advanced cirrhosis or clinical decompensation, who are arguably the group most in...
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