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Article

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2015

Beane Joal D, Lee Gary, Zheng Zhili, Mendel Matthew, Abate-Daga Daniel, Bharathan Mini, Black Mary, Gandhi Nimisha, Yu Zhiya, Chandran Smita, Giedlin Martin, Ando Dale, Miller Jeff, Paschon David, Guschin Dmitry, Rebar Edward J, Reik Andreas, Holmes Michael C, Gregory Philip D, Restifo Nicholas P, Rosenberg Steven A, Morgan Richard A, Feldman Steven A

Abstract excerpt

Programmed cell death-1 (PD-1) is expressed on activated T cells and represents an attractive target for gene-editing of tumor targeted T cells prior to adoptive cell transfer (ACT). We used zinc finger nucleases (ZFNs) directed against the gene encoding human PD-1 (PDCD-1) to gene-edit melanoma...

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Source

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Identifiers

PMID: 25939491
DOI: 10.1038/mt.2015.71
PMCID: PMC4817870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25939491-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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