Article
The adhesion GPCR latrophilin/CIRL shapes mechanosensation.
Cell reports - 12 May 2015
Scholz Nicole, Gehring Jennifer, Guan Chonglin, Ljaschenko Dmitrij, Fischer Robin, Lakshmanan Vetrivel, Kittel Robert J, Langenhan Tobias
Abstract excerpt
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that...
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