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Article

A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium.

Nucleic acids research - 26 May 2015

Torres-Puig Sergi, Broto Alicia, Querol Enrique, Piñol Jaume, Pich Oscar Q

Abstract excerpt

The Mycoplasma genitalium MG428 protein shows homology to members of the sigma-70 family of sigma factors. Herein, we found that MG428 activates transcription of recA, ruvA and ruvB as well as several genes with unknown function. Deletion of MG_428 or some of the up-regulated unknown genes led to severe recombination defects. Single cell analyses revealed that activation of the MG428-regulon is a rare event under...

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Identifiers

PMID: 25925568
DOI: 10.1093/nar/gkv422
PMCID: PMC4446450

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Source receipt: pubmed, retrieved 7 Sept 2026.

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