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Article

An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia.

Human genetics - 1 Jul 2015

Mascheretti S, Bureau A, Trezzi V, Giorda R, Marino C

Abstract excerpt

Even if substantial heritability has been reported and candidate genes have been identified extensively, all known marker associations explain only a small proportion of the phenotypic variance of developmental dyslexia (DD) and related quantitative phenotypes. Gene-by-gene interaction (also known as "epistasis"--G × G) triggers a non-additive effect of genes at different loci and should be taken into account in...

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Source

Identifiers

PMID: 25916574
DOI: 10.1007/s00439-015-1555-4

Genes

DCDC2
ROBO1

Provenance

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