Article
6R-tetrahydrobiopterin treated PKU patients below 4 years of age: Physical outcomes, nutrition and genotype.
Molecular genetics and metabolism - 1 May 2015
Aldámiz-Echevarría Luis, Bueno María A, Couce María L, Lage Sergio, Dalmau Jaime, Vitoria Isidro, Llarena Marta, Andrade Fernando, Blasco Javier, Alcalde Carlos, Gil David, García María C, González-Lamuño Domingo, Ruiz Mónica, Ruiz María A, Peña-Quintana Luis, González David, Sánchez-Valverde Felix
Abstract excerpt
BACKGROUND AND AIMS: Phenylalanine-restricted diets have proven effective in treating phenylketonuria. However, such diets have occasionally been reported to hinder normal development. Our study aimed to assess whether treating 0-4-year-old phenylketonuric patients with 6R-tetrahydrobiopterin might prevent growth retardation later in life. METHODS: We conducted a longitudinal retrospective study which examined...
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