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Article

Performance of antenatal reflex DNA screening for Down’s syndrome

16 Apr 2015

Abstract excerpt

OBJECTIVE: Maternal plasma DNA analysis has a high but imperfect antenatal Down's syndrome screening performance. We aimed to determine the effect of combining DNA testing with current tests. METHODS: In our modelled screening protocol, women provide two samples, one serum sample for a Combined test, and a plasma sample for a possible DNA test. Women with a Combined test risk above a specified level have a DNA...

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PMID: 25882667
DOI: 10.1177/0969141315581005

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