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Improved production of sublancin via introduction of three characteristic promoters into operon clusters responsible for this novel distinct glycopeptide biosynthesis

11 Feb 2015

Abstract excerpt

BACKGROUND: Sublancin is a novel and distinct antimicrobial glycopeptide that can be used as an alternative to conventional antibiotics. The reported production of sublancin by Bacillus subtilis 168 is poor because transcriptional regulatory circuit of sunA, a gene that encodes presublancin, is complex and difficult to control. RESULTS: A strong inducible and easy to control vegetative σA promoter of Pglv was...

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PMID: 25879813
DOI: 10.1186/s12934-015-0201-0

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