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Article

Methotrexate treatment affects effector but not regulatory T cells in juvenile idiopathic arthritis.

Rheumatology (Oxford, England) - 1 Sept 2015

Bulatović Ćalasan Maja, Vastert Sebastiaan J, Scholman Rianne C, Verweij Frederik, Klein Mark, Wulffraat Nico M, Prakken Berent J, van Wijk Femke

Abstract excerpt

OBJECTIVE: The balance between Treg and effector T cells (Teff) is crucial for immune regulation in JIA. How MTX, the cornerstone treatment in JIA, influences this balance in vivo is poorly elucidated. The aim of this study was to investigate quantitative and qualitative effects of MTX on Treg an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25877908
DOI: 10.1093/rheumatology/kev101

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25877908-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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