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Paternal age and telomere length in twins: the germ stem cell selection paradigm

10 Apr 2015

Abstract excerpt

Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an 'epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in...

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PMID: 25865872
DOI: 10.1111/acel.12334

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