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Article

(1)H-MRS in glutaric aciduria type 1: impact of biochemical phenotype and age on the cerebral accumulation of neurotoxic metabolites.

Journal of inherited metabolic disease - 1 Sept 2015

Harting Inga, Boy Nikolas, Heringer Jana, Seitz Angelika, Bendszus Martin, Pouwels Petra J W, Kölker Stefan

Abstract excerpt

BACKGROUND: In glutaric aciduria type 1 (GA1) the neurotoxic metabolites glutaric acid (GA) and 3-hydroxyglutaric acid (3-OH-GA) accumulate within the brain. Due to limited efflux across the blood-brain-barrier biochemical monitoring of intracerebrally accumulating toxic metabolites is as yet not possible. AIMS: To investigate brain metabolic patterns in glutaric aciduria type 1 using (1)H magnetic resonance...

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Identifiers

PMID: 25860816
DOI: 10.1007/s10545-015-9826-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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