Article
Impact of the CFTR-potentiator ivacaftor on airway microbiota in cystic fibrosis patients carrying a G551D mutation.
PloS one - 1 Jan 2015
Bernarde Cédric, Keravec Marlène, Mounier Jérôme, Gouriou Stéphanie, Rault Gilles, Férec Claude, Barbier Georges, Héry-Arnaud Geneviève
Abstract excerpt
BACKGROUND: Airway microbiota composition has been clearly correlated with many pulmonary diseases, and notably with cystic fibrosis (CF), an autosomal genetic disorder caused by mutation in the CF transmembrane conductance regulator (CFTR). Recently, a new molecule, ivacaftor, has been shown to re-establish the functionality of the G551D-mutated CFTR, allowing significant improvement in lung function. OBJECTIVE...
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