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Article

Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe.

Nature communications - 7 Apr 2015

Kay Gemma L, Sergeant Martin J, Zhou Zhemin, Chan Jacqueline Z-M, Millard Andrew, Quick Joshua, Szikossy Ildikó, Pap Ildikó, Spigelman Mark, Loman Nicholas J, Achtman Mark, Donoghue Helen D, Pallen Mark J

Abstract excerpt

Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25848958
DOI: 10.1038/ncomms7717
PMCID: PMC4396363

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