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Article

Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics.

International journal of antimicrobial agents - 1 Jun 2015

Cusato Jessica, Allegra Sarah, De Nicolò Amedeo, Boglione Lucio, Fatiguso Giovanna, Abdi Adnan Mohamed, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

Boceprevir (BOC) is a directly-acting antiviral agent for the treatment of hepatitis C virus genotype 1 (HCV-1) infection. It is a mixture of two stereoisomers, the inactive R and the active S isomers. No data have previously been published on BOC intracellular accumulation. In this study, BOC is...

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Source

Identifiers

PMID: 25836019
DOI: 10.1016/j.ijantimicag.2015.01.019

Genes

BOC
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25836019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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