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Article

Genetic and Epigenetic Modulation of Growth Hormone Sensitivity Studied With the IGF-1 Generation Test.

The Journal of clinical endocrinology and metabolism - 1 Jun 2015

Ouni Meriem, Castell Anne-Laure, Linglart Agnès, Bougnères Pierre

Abstract excerpt

CONTEXT: Like all hormones, GH has variable physiological effects across people. Many of these effects initiated by the binding of GH to its receptor (GHR) in target tissues are mediated by the expression of the IGF1 gene. Genetic as well as epigenetic variation is known to contribute to the individual diversity of GH-dependent phenotypes through two mechanisms. The first one is the genetic polymorphism of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25835289
DOI: 10.1210/jc.2015-1413
PMCID: PMC4454803

Genes

GHR
IGF1

Provenance

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