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Article

Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study.

Pharmacogenomics - 1 Jan 2015

Habtewold Abiy, Makonnen Eyasu, Amogne Wondwossen, Yimer Getnet, Aderaye Getachew, Bertilsson Leif, Burhenne Jürgen, Aklillu Eleni

Abstract excerpt

AIMS: The current HIV treatment guidelines are inconsistent about the need for weight-based efavirenz dose adjustment during rifampicin containing antituberculosis (anti-TB) cotreatment. We investigated effect of rifampicin-based anti-TB cotreatment on plasma efavirenz exposure and treatment outcome, considering effect of CYP2B6 genotype and bodyweight. PATIENTS & METHODS: HIV-only (arm 1, n = 285) or TB-HIV (arm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25831219
DOI: 10.2217/pgs.15.35

Genes

CYP2B6
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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