Article
Structural basis for the geometry-driven localization of a small protein.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2015
Gill Richard L, Castaing Jean-Philippe, Hsin Jen, Tan Irene S, Wang Xingsheng, Huang Kerwyn Casey, Tian Fang, Ramamurthi Kumaran S
Abstract excerpt
In bacteria, certain shape-sensing proteins localize to differently curved membranes. During sporulation in Bacillus subtilis, the only convex (positively curved) surface in the cell is the forespore, an approximately spherical internal organelle. Previously, we demonstrated that SpoVM localizes to the forespore by preferentially adsorbing onto slightly convex membranes. Here, we used NMR and molecular dynamics...
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