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Article

Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.

Molecular cancer therapeutics - 1 Apr 2015

Karginova Olga, Siegel Marni B, Van Swearingen Amanda E D, Deal Allison M, Adamo Barbara, Sambade Maria J, Bazyar Soha, Nikolaishvili-Feinberg Nana, Bash Ryan, O'Neal Sara, Sandison Katie, Parker Joel S, Santos Charlene, Darr David, Zamboni William, Lee Yueh Z, Miller C Ryan, Anders Carey K

Abstract excerpt

Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently harbors BRCA mutations translating to platinum sensitivity potentially augmented by additional suppression of DNA repair mechanisms through PARP inhibition. We evaluated brain...

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Identifiers

PMID: 25824335
DOI: 10.1158/1535-7163.MCT-14-0474
PMCID: PMC4394032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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