Article
Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1.
Prostaglandins & other lipid mediators - 1 Jul 2015
Marcantoni Emanuela, Dovizio Melania, O'Gaora Peadar, Di Francesco Luigia, Bendaya Imen, Schiavone Simone, Trenti Annalisa, Guillem-Llobat Paloma, Zambon Alessandra, Nardelli Giovanni Battista, Trevisi Lucia, Patrignani Paola, Belton Orina
Abstract excerpt
Enhanced biosynthesis of several cytokines, such as, transforming growth factor-β1 (TGF-β1), is detected in gestational diabetes mellitus (GDM). In this study, we addressed the question of whether the exposure to the abnormal milieu of GDM in vivo affects gene expression pattern of human umbilical vein endothelial cells (HUVEC) in response to TGF-β1. We found that HUVEC isolated from GDM (dHUVEC) had reduced...
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