Article
The Signature Program: Bringing the Protocol to the Patient.
Clinical pharmacology and therapeutics - 1 Aug 2015
Kang B P, Slosberg E, Snodgrass S, Lebedinsky C, Berry D A, Corless C L, Stein S, Salvado A
Abstract excerpt
Early-phase clinical development in oncology has evolved dramatically with the deciphering of the human genome in 2004. Genomic analysis and the tools identifying genetically disrupted pathways within a patient's tumor have been a driving force for personalized medicine and for the development of highly targeted novel therapies. Tumors are often genetically heterogeneous, with multiple concurrent genetic...
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