Article
Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis.
Cell transplantation - 1 Jan 2006
Carvey Paul M, Punati Ashok, Newman Mary B
Abstract excerpt
Animal models have been an essential tool for researchers and clinicians in their efforts to study and treat Parkinson's disease (PD). Thus, the various ways 6-hydroxydopamine is employed, the use of MPTP in rodents and nonhuman primates, the prenatal exposure to bacterial endotoxin, the postnatal exposure to environmental toxins such as paraquat and rotenone, the assessment of dopamine (DA) neurons in genetic...
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