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Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains

17 Mar 2015

Abstract excerpt

Plasmodium falciparum, the causative agent of severe human malaria, employs antigenic variation to avoid host immunity. Antigenic variation is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of chromatin. The histone-modifying 'sirtuin' enzymes PfSir2a and PfSir2b have been implicated in this process. Disparate patterns of var expression have been reported...

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PMID: 25780929
DOI: 10.1371/journal.pone.0118865

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