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Article

[Should knowledge of BRCA1 status impact the choice of chemotherapy in metastatic breast cancer: a review].

Bulletin du cancer - 1 Mar 2015

Clergue Océane, Jones Natalie, Sévenet Nicolas, Quenel-Tueux Nathalie, Debled Marc

Abstract excerpt

BRCA1 and BRCA2 mutations account for 40% of cancer predisposition gene mutations identified in the current French diagnostic setting. The proteins encoded by these genes are implicated in DNA repair pathways. As a result, loss of BRCA1 or BRCA2 function may modify chemo-sensitivity. This literat...

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Source

Identifiers

PMID: 25758301
DOI: 10.1016/j.bulcan.2015.01.010

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25758301-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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