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Article

Phase I study of everolimus, cetuximab and irinotecan as second-line therapy in metastatic colorectal cancer.

Anticancer research - 1 Mar 2015

Hecht J Randolph, Reid Tony R, Garrett Christopher R, Beck J Thaddeus, Davidson Sheldon J, Mackenzie Mary J, Brandt Ulrike, Rizvi Syed, Sharma Sunil

Abstract excerpt

AIM: To evaluate feasible doses of weekly everolimus and irinotecan given with cetuximab for previously treated metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: Adults with mCRC that progressed after 5-fluorouracil or capecitabine-plus-oxaliplatin were treated using a sequential dose escalation scheme. Dosing decisions were based on the probability of experiencing a dose-limiting toxicity (DLT) during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25750312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phase I study of everolimus, cetuximab and irinotecan as second-line therapy in metastatic colorectal cancer.PMID 25750312Read ↗

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Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.Semantic proximity Read ↗

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