Article
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication.
PloS one - 1 Jan 2018
Sanna Cinzia, Scognamiglio Monica, Fiorentino Antonio, Corona Angela, Graziani Vittoria, Caredda Alessia, Cortis Pierluigi, Montisci Mariofilippo, Ceresola Elisa Rita, Canducci Filippo, Poli Ferruccio, Tramontano Enzo, Esposito Francesca
Abstract excerpt
In a search for new potential multitarget anti-HIV compounds from natural products, we have identified in Hypericum scruglii, an endemic and exclusive species of Sardinia (Italy), a potent plant lead. The phytochemical study of the hydroalcoholic extract obtained from its leaves led to the isolation of its most abundant secondary metabolites, belonging to different chemical classes. In particular, three...
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