Article
DNA and RNA editing of retrotransposons accelerate mammalian genome evolution.
Annals of the New York Academy of Sciences - 1 Apr 2015
Knisbacher Binyamin A, Levanon Erez Y
Abstract excerpt
Genome evolution is commonly viewed as a gradual process that is driven by random mutations that accumulate over time. However, DNA- and RNA-editing enzymes have been identified that can accelerate evolution by actively modifying the genomically encoded information. The apolipoprotein B mRNA editing enzymes, catalytic polypeptide-like (APOBECs) are potent restriction factors that can inhibit retroelements by...
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