Article
Pan-genome analysis of human gastric pathogen H. pylori: comparative genomics and pathogenomics approaches to identify regions associated with pathogenicity and prediction of potential core therapeutic targets.
BioMed research international - 1 Jan 2015
Ali Amjad, Naz Anam, Soares Siomar C, Bakhtiar Marriam, Tiwari Sandeep, Hassan Syed S, Hanan Fazal, Ramos Rommel, Pereira Ulisses, Barh Debmalya, Figueiredo Henrique César Pereira, Ussery David W, Miyoshi Anderson, Silva Artur, Azevedo Vasco
Abstract excerpt
Helicobacter pylori is a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cause of gastric cancer (~70%) around the world. Conversely, an increased resistance to antibiotics and hindrances in the development of vaccines against H. pylori are observed. Pan-genome analyses of the global representative H. pylori isolates consisting of 39 complete genomes are presented in this...
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