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Article

Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2015

Cheng Yuan, Feng Yi, Jansson Lina, Sato Yorino, Deguchi Masashi, Kawamura Kazuhiro, Hsueh Aaron J

Abstract excerpt

Hippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes. Studies have demonstrated that fragmentation of murine ovaries increases actin polymerization and disrupts Hippo signaling, leading to nuclear translocation of Hippo signaling effector Yes-associated protein (YAP) in ovarian follicles and follicle growth. For patients with polycystic ovarian syndrome showing...

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Identifiers

PMID: 25690654
DOI: 10.1096/fj.14-267856
PMCID: PMC4447223

Genes

CCN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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