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Article

A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells In Vitro.

Cancer research and treatment - 1 Oct 2015

Dinavahi Saketh S, Prasanna Rajagopalan, Dharmarajan Sriram, Perumal Yogeeswari, Viswanadha Srikant

Abstract excerpt

PURPOSE: Anomalies of Akt regulation, including overexpression in lung cancer, impart resistance to conventional chemotherapy and radiation, thereby implicating this kinase as a therapeutic intervention point. A novel scaffold of Akt inhibitors was developed through virtual screening of chemical databases available at Birla Institute of Technology and Science, Pilani, Hyderabad, based on docking studies using...

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Identifiers

PMID: 25687876
DOI: 10.4143/crt.2014.057
PMCID: PMC4614210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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